Center for Clinical Genetics
and Genomics

Laboratory Genetics and Genomics LGG Fellowship

The Magee-Womens Hospital Clinical Genetics and Genomics Laboratory is composed of the Clinical Cytogenetic Laboratory (PCL), the Clinical Genomics Laboratory (PCGL) and the Prenatal Screening Lab (PSL).  The laboratories are accredited by the American Board of Medical Genetics and Genomics (ABMGG) for the training of Laboratory Genetics and Genomics (LGG) fellows.

The two-year Laboratory Genetics and Genomics LGG Fellowship program is designed for individuals who wish to become directors of clinical cytogenetic and molecular genetic laboratories.  Our program also takes advantage of the close proximity of the Molecular Genetic Pathology Laboratory (MGP) to integrate the fellow’s training activities and to ensure exposure to a variety of prenatal, postnatal and oncology cases.

PCL offers comprehensive traditional cytogenetics and molecular cytogenetics tests that include karyotyping, fluorescence in situ hybridization and whole genome CGH+SNP microarray analysis.  Fellows receive in-depth training in cytogenetic and molecular cytogenetic techniques and procedures applied to prenatal testing, postnatal testing in children and adults, and oncology testing.  

PCGL offers testing for cystic fibrosis, pharmacogenetics, and preimplantation genetic diagnosis. In 2017, the laboratory will start offering large gene panels and exome analysis using next generation sequencing (NGS). This will give fellows exposure to a number of genetic disorders. In addition to NGS, a variety of technologies are used in the lab including mass spectrometry, Sanger sequencing, electrochemical detection, whole genome amplification and automated DNA isolation.

Training Objectives

  • Perform, analyze, interpret and report cytogenetic and molecular assays.
  • Identify, annotate and interpret cytogenetic, sequence and copy number variations using databases and informatics pipelines.
  • Communicate genetic test results to physicians and other professional staff.
  • Develop oral and written presentation skills through case conferences, seminars, abstracts and manuscripts.
  • Understand clinical laboratory management including lab regulatory issues and quality control procedures.
  • Understand the development and validation of new clinical assays
  • Participate in translational research projects.

 

During the two-year training program, fellows will participate in the case conferences on clinical genetics, clinical microarray, and hematopathology, Children’s Hospital tumor board and genetic counseling sessions. In addition, the candidate is required to take several graduate level courses at the Graduate School of Public Health at the University of Pittsburgh in the area of human genetics.

Upon the successful completion of the two-year training program, fellows will be eligible for the LGG ABMGG certification exam and be able to direct a cytogenetic and/or molecular genetic laboratory.

Relevant information can also be found at:

 

Contact Information

Medical Genetics Residency and LGG Fellowship Coordinator

Marjorie Seskey
Magee-Womens Research Institute
204 Craft Avenue- Room 308
Pittsburgh, PA 15213
412-641-7531
seskeyma@mwri.magee.edu